Antitumor effect potentiators

Details Antitumor effect potentiators Antitumor effect potentiators

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2413313

When used concurrently with an antitumor agent, a compound having a Rho kinase inhibitory activity, such as (R)-(+)-N-(4-pyridyl)-4-(1-aminoethyl)benzamide, reinforces an antitumor effect of the antitumor agent and is useful as an antitumor effect potentiator. Particularly, a compound having a Rho kinase inhibitory activity used with an antitumor agent in combination can reduce the dose of the antitumor agent, which in turn affords provision of a sufficient effect and/or reduction of side effects.

Lorsqu'ils sont utilisés avec des agents antitumoraux, les composés présentant une activité inhibitrice de la Rho kinase, tels que (R)-(+)-N-(4-pyridyle)-4-(1-aminoéthyle)benzamide, peuvent renforcer l'effet antitumoral des agents antitumoraux. De ce fait, ces composés sont utiles comme potentialisateurs d'effet antitumoral. En particulier, l'utilisation combinée de ces composés susmentionnés avec les agents antitumoraux permet de réduire la dose d'agents antitumoraux et ainsi, d'obtenir des effets suffisants et/ou de soulager les effets secondaires.

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