Antiviral compounds

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1333361

2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides parti- cularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. The nucleo- sides are of general formula (I): Image (I) Image wherein R represents a hydrogen atom, a C1-4 alkyl group or a halogen atom or a physiologically acceptable salt or ester there- of. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

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