Apovincaminic acid derivatives and process for preparing same

Details Apovincaminic acid derivatives and process for preparing same Apovincaminic acid derivatives and process for preparing same

C - Chemistry, Metallurgy

07

D

260/272

C07D 461/00 (2006.01)

Patent

CA 1199920

A b s t r a c t The invention relates to new racemic and optically active apovincaminic acid derivatives of the general formula (I) (I) Image wherein A is hydroxyl, halogen or a group -O-(CH2)n-OR1 or -OMe, in which Rl is alkyl having from 1 to 6 carbon atoms, n is an integer between 2 and 6, Me is an alkali metal R2 stands for an alkyl group having from 1 to 6 carbon atoms which may be identical with or different from Rl, and the hydrogen in the 3-position and the R2 group have an .alpha..alpha.,.alpha..alpha. and/or .beta.,.beta.- or .alpha..alpha.,.beta.- and/or .beta.,.alpha..alpha.- configu- ration, and pharmaceutically acceptable acid addition salts thereof, which are pharmaceutically active, e.g. - 2 - show antihypoxial activity or are potent peripheral vasodilators. Their preparation and pharmaoeutical composition containing them are also within the scope of tine invention.

431479

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