Apovincaminol-3',4',5'-trimethoxy-benzoate compounds

Details Apovincaminol-3',4',5'-trimethoxy-benzoate compounds Apovincaminol-3',4',5'-trimethoxy-benzoate compounds

C - Chemistry, Metallurgy

07

D

260/272

C07D 461/00 (2006.01)

Patent

CA 1202028

ABSTRACT The invention relates to new compounds of the general Formula /I/ Image /I/ /wherein either both R1 and R2 stand for hydrogen or one or the symbols R1 and R2 is hydrogen and the other is nitro/ and pharmaceutically acceptable acid addition salts thereof. The new compounds of the general Formula /I/ can be prepared by reacting apovincaminol with 3,4,5-trimethoxy-benzoic acid or a reactive derivative thereof capable of acylation and if desired, nitrating the com- pound of the Formula /Ia/ Image /Ia/ thus obtained and separating the isomeric mixture thus obtained into the com- pounds of the Formulae /Ib/ and /Ic/ Image /Ib/ Image /Ic/ and if desired, converting a compound of the Formula /Ia/, /Ib/ or /Ic/ thus obtained into a pharmaceutically acceptable acid addition salt thereof. The new compounds of the present invention can be used in therapy in the treatment of skin diseases attached to pathological cell prolifera- tion and in the prophylaxis of such diseases.

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