Apovincaminol derivatives, process for their preparation and...

Details Apovincaminol derivatives, process for their preparation and... Apovincaminol derivatives, process for their preparation and...

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 461/00 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1265520

ABSTRACT OF THE DISCLOSURE The invention relates to new apovincaminol derivatives of the formula (I) Image (I) wherein R1 is hydrogen or nitro; R2 is C1-15 alkyl, or phenyl substituted by nitro, methoxy or phenyl; R3 is hydroxy or -OR5, in which R5 is acetyl, benzoyl, or palmitoyl; and R4 is hydrogen or R3 and R4 together form a valency bond; R3 and R4 together do not form a valency bond if R2 is 3,4,5-trimethoxyphenyl group and R1 is hydrogen, or an acid addition salt thereof. The compound(I) may be used in the therapy of various skin diseases accompanied by a pathological cell proliferation, preferably psoriasis.

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