A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) A61F 2/06 (2006.01) A61K 31/407 (2006.01) A61K 47/30 (2006.01) A61L 27/34 (2006.01) A61L 27/44 (2006.01) B05D 3/00 (2006.01)
Patent
CA 2500067
The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device (99). A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug (55) incorporated into the biocompatible drug release matrix. The drug (55) has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug (55) is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug (55) release rate maintains tissue level concentrations of the drug (55) for at least two weeks after implantation of the medical device (99). The present invention provides a coating for a vascular prosthesis that elutes the drug (55) at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.
L'invention concerne un appareil et un procédé de distribution de mitomycine au moyen d'un dispositif médical (99) d'élution biocompatible implantable. Une matrice biocompatible de libération de médicament est constituée d'une matrice et d'un médicament (55) incorporé dans celle-ci. Ce médicament (55) présente des propriétés antibiotiques et anti-prolifératives et est un analogue associé aux agents d'alkylation contenant de la quinone d'une famille de mitomycine. Ledit médicament (55) est initialement libéré de la matrice biocompatible de libération de médicament à une vitesse élevée puis à une vitesse plus lente. La vitesse de libération dudit médicament (55) permet de maintenir des concentrations tissulaires du médicament (55) pendant au moins deux semaines après implantation du dispositif médical (99). L'invention concerne un revêtement pour une prothèse vasculaire qui permet d'éluer ledit médicament (55) à une vitesse régulée afin d'inhiber la prolifération de cellules musculaires lisses provoquant la resténose.
Furnish Simon M.
Granada Juan F.
Endovascular Devices Inc.
Torys Llp
LandOfFree
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