Apparatus and method for transdermal delivery of natriuretic...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61K 9/19 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2576852

An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide- containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.

L'invention concerne un appareil et un procédé d'administration par voie transdermique d'un peptide natriurétique comprenant un système d'administration pourvu d'un élément à microprojections (ou réseau de microprojections) adapté pour percer la couche cornée de la couche épidermique sous-jacente, de l'épiderme ou du derme. Dans un mode de réalisation, le peptide natriurétique est contenu dans un revêtement biocompatible appliqué sur l'élément à microprojections. Dans un autre mode de réalisation, le système d'administration comprend une formulation hydrogel contenant le peptide natriurétique. En variante, le peptide natriurétique est contenu dans le revêtement et la formulation hydrogel. Dans un autre mode de réalisation, le peptide natriurétique est contenu dans une formulation à l'état solide.

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