Aromatase inhibiting 4(5)-imidazoles

Details Aromatase inhibiting 4(5)-imidazoles Aromatase inhibiting 4(5)-imidazoles

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01)

Patent

CA 2051803

Abstract AROMATASE INHIBITING 4(5)-IMIDAZOLES Novel imidazole derivatives of the formula Image (I) wherein R1, R2, R'1 and R'2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF:2, CHF2 or halogen; R' is H or Image , where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and demolase inhibiting properties. Selective aromatase inhibiting compounds are valuable an the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).

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