Aroyl-piperazine derivatives, their preparation and their...

Details Aroyl-piperazine derivatives, their preparation and their... Aroyl-piperazine derivatives, their preparation and their...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 241/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2292883

This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R1 is aryl which may have substituent(s), R2 is aryl or indolyl, each of which may have substituent(s), R3 is hydrogen or lower alkyl, and R4 is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human beings or animals.

L'invention concerne des dérivés de pipérazine représentés par la formule (I): dans laquelle Y représente une liaison ou alkylène inférieur, R?1¿ représente aryle possédant éventuellement un ou plusieurs substituants, R?2¿ représente aryle ou indolyle, dont chacun possède éventuellement un ou plusieurs substituants, R?3¿ représente hydrogène ou alkyle inférieur et R?4¿ représente X comme défini dans le descriptif, ainsi que leur sel acceptable sur le plan pharmaceutique, des procédés servant à les préparer, une composition pharmaceutique les contenant, ainsi que leur mise en application prophylactique ou thérapeutique dans le cas de maladies provoquées par la tachykinine chez l'homme ou l'animal.

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