Aryl alkyl carbamate derivatives production and use thereof...

Details Aryl alkyl carbamate derivatives production and use thereof... Aryl alkyl carbamate derivatives production and use thereof...

C - Chemistry, Metallurgy

07

C

C07C 271/10 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 269/00 (2006.01) C07C 269/06 (2006.01) C07C 271/12 (2006.01) C07C 271/14 (2006.01) C07C 271/16 (2006.01) C07C 271/18 (2006.01) C07C 271/20 (2006.01) C07D 213/40 (2006.01) C07D 215/12 (2006.01) C07D 217/18 (2006.01) C07D 241/12 (2006.01) C07D 261/08 (2006.01) C07D 263/44 (2006.01) C07D 285/06 (2006.01) C07D 307/91 (2006.01) C07D 333/20 (2006.01) C07D 333/58 (2006.01)

Patent

CA 2511941

The invention relates to compounds of general formula (I), where n = a whole number from 1 to 7, A is selected from one or several groups X, Y and/or Z, X = C¿1-2? alkylene, optionally substituted by one or more C¿1-12? alkyl, C¿3-7? cycloalkyl or C¿3-7? cycloalkyl-C¿1-6? alkylene groups, Y = C¿2? alkenylene, optionally substituted by one or several C¿1-12? alkyl, C¿3-7? cycloalkyl or C¿3-7?cycloalkyl-C¿1-6? alkylene groups, Z = a C¿3-7? cycloalkyl group of formula, (II), (III), m = a whole number from 1 to 5, p and q are whole numbers defined such that p+q is a number from 1 to 5, R¿1? = H, halogen, hydroxyl, cyano, nitro, C¿1-4? alkyl, C¿1-4? alkoxy?, ¿C¿1-4? thioalkyl, C¿1-4?fluoroalkyl, C¿1-4? fluoroalkoxy, C¿1-4? fluorothioalkyl, R¿2? = H, halogen, cyano, nitro, hydroxyl, C¿1-4? alkyl, C¿1-4? alkoxy, C¿1-4? thioalkyl, C¿1-4? fluoroalkyl, C¿1-4? fluoroalkoxy, C¿1-4?-fluorothioalkyl, or an aryl or heteroaryl group, optionally substituted by one or several substituents, R¿3? is a group of general formula CHR¿4?CONHR¿5?, where R¿4? = H, or C¿1-3? alkyl and R¿5? = H, or C¿1-3? alkyl, C¿3-5? cycloalkyl, C¿3-7?-cycloalkyl-C¿1-6? alkylene, the base, the acid addition salt, the hydrate or the solvate thereof. For application in therapy.

Composé répondant à la formule générale (I) ayant un effet inhibiteur de l~enzyme FAAH (Fatly Acid Amido hydrolase).

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