C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/00 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2573271
The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazoly'1, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3~a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2- b]pyridinyl, 1H-pyrrolo[2,3~b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH- quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
La présente invention a trait à des composés de structure chimique représentée par la formule (I), dans laquelle, l'atome de carbone désigné * est dans la configuration R ou S; X est un carbocycle ou hétérocycle bicyclique accolé choisi parmi le groupe constitué de benzofuranyle, benzo[b]thiophényle, benzoisothiazolyle, benzoisoxazolyle, indazolyle, indolyle, isoindolyle, indolizinye, benzoimidazolyle, benzooxazolyle, benzothiazolyle, benzotriazolyle, imidazo[1,2-a]pyridinyle, pyrazolo[1,5-a]pyridinyle, [1,2,4]triazolo[4,3-a]pyridinyle, thiéno[2,3-b]pyridinyle, thiéno[3,2-b]pyridinyle, 1<I>H</I>-pyrrolo[2,3-b]pyridinyle, indényle, indanyle, dihydrobenzocycloheptényle, tétrahydrobenzocycloheptényle, dihydrobenzothiophényle, dihydrobenzofuranyle, indolinyle, naphtyle, tétrahydronaphtyle, quinolinyle, isoquinolinyle, 4<I>H</I>-quinolizinyle, 9a<I>H</I>-quinolizinyle, quinazolinyle, cinnolinyle, phtalazinyle, quinoxalinyle, benzo[1,2,3]triazinyle, benzo[1,2,4]triazinyle, 2<I>H</I>-chroményle, 4<I>H</I>-chroményle, et un carbocycle bicyclique accolé ou un hétérocycle bicyclique accolé substitué avec des substituants (en nombre de 1 à 4) tels que définis en R14; R2, R3, R4, R5, R6, R7, R8, et R14 étant tels que définis dans la description.
Beck James P.
Berkowitz Barry A.
Cohen Marlene
Guzzo Peter R.
Liu Shuang
Amr Technology Inc.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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