C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/34 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) C07D 263/44 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2483771
Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidine-dione and aryl- link-aryl oxazolidine-dione compounds and a pharmaceutically acceptable carrier; and a method of treatment of acute pain, chronic pain, visceral pain, inflammatory pain, or neuropathic pain, as well as irritable bowel syndrome, Crohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar depression, and tachy-arrhythmias by the administration of an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are described.
La présente invention concerne des composés aryle-liaison-aryle thiazolidine-dione et aryle-liaison-aryle oxazolidine-dione qui sont des bloqueurs des canaux sodiques; des compositions pharmaceutiques qui comprennent une quantité efficace des composés aryle-liaison-aryle thiazolidine-dione et aryle-liaison-aryle oxazolidine-dione ainsi qu'un support pharmaceutiquement acceptable; et une méthode de traitement de la douleur aiguë, de la douleur chronique, de la douleur viscérale, de la douleur inflammatoire ou de la douleur neuropathique ainsi que du syndrome du côlon irritable, de la maladie de Crohn, de l'épilepsie, des crises toniques partielles ou généralisées, de la sclérose en plaques, de la dépression bipolaire et des tachyarythmies, au moyen de l'administration d'une quantité efficace des composés aryle-liaison-aryle thiazolidine-dione et aryle-liaison-aryle oxazolidine-dione.
Ayer Michelle B.
Chakravarty Prasun K.
Kuo Howard C. H.
Meinke Peter T.
Parsons William H.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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