C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/439 (2006.01) A61K 31/4995 (2006.01) C07D 451/02 (2006.01)
Patent
CA 2704320
Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.
L'invention porte sur des composés de type diamines pontées ou fusionnées substituées par aryle, sur des compositions pharmaceutiques les contenant et sur des procédés d'utilisation des composés et des compositions pharmaceutiques pour une modulation de la leukotriène A4 hydrolase (LTA4H ou LTA4H) et pour le traitement d'états de maladie, de troubles et d'états à médiation par l'activité LTA4H, tels qu'une allergie, l'asthme, des maladies auto-immunes, le prurit, une affection abdominale inflammatoire, une colite ulcérative et une maladie cardiovasculaire, comprenant l'athérosclérose et la prévention de l'infarctus du myocarde.
Bacani Genesis M.
Bembenek Scott D.
Eccles Wendy
Edwards James P.
Epperson Matthew T.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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