Arylacetic amide derivative or salt thereof, and...

Details Arylacetic amide derivative or salt thereof, and... Arylacetic amide derivative or salt thereof, and...

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 211/94 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2253156

Described is an arylacetic amide derivative represented by the following formula (1): (see fig. I) wherein R1 represents an aryl group or the like, R2 and R3 each independently represents an alkyl group, a cycloalkyl group or the like, and R4 represents an aralkyl group, an alkyl group or the like; or salt thereof. The compound according to the present invention has both excellent anticholinergic action and calcium antagonism and at the same time has high selectivity to bladder, so that it is useful as a preventive or remedy for urinary disorders.

Divulgation d'un dérivé d'amide arylacétique ou d'un sel de celui-ci, représenté par la formule suivante (1) (voir figure I), dans laquelle : R1 représente un aryle ou un groupement similaire, R2 et R3 représentent, de manière indépendante, un alkyle, un cycloalkyle ou un groupement similaire et R4 représente un aralkyle, un alkyle ou un groupement similaire. Le composé divulgué a une action anticholinergique et un antagonisme du calcium excellents et présente simultanément une haute sélectivité pour la vessie, le rendant utile comme moyen de prévention ou de traitement de troubles urinaires.

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