C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/385 (2006.01) C07C 275/24 (2006.01) C07C 275/28 (2006.01) C07C 275/40 (2006.01) C07D 307/54 (2006.01) C07D 307/79 (2006.01) C07K 16/44 (2006.01) C12Q 1/37 (2006.01) G01N 33/577 (2006.01) G01N 33/62 (2006.01)
Patent
CA 2076403
151/CCP69 18525 TITLE OF THE INVENTION ASSAY FOR EVALUATING INHIBITION OF PMN ELASTASE BY N-SUBSTITUTED AZETIDINONES ABSTRACT OF THE INVENTION N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the assay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured. The assays are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.
Finke Paul E.
Hagmann William K.
Hanlon William A.
Humes John L.
Knight Wilson B.
Finke Paul E.
Gowling Lafleur Henderson Llp
Hagmann William K.
Hanlon William A.
Humes John L.
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