Assays for apoptosis modulators

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/10 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/483 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2375708

Recombinant cells expressing fluorescence resonance energy transfer reporter polypeptides and cell-based for apoptosis; screening assays for identifying and selecting candidate compounds modulating apoptosis.

L'invention concerne des cellules recombinées qui expriment des polypeptides rapporteurs à fluorescence de résonance à transfert d'énergie. L'invention concerne également des tests cellulaires de l'apoptose . Cette invention concerne enfin des essais de criblage permettant d'identifier et de sélectionner des composés potentiellement aptes à moduler l'apoptose.

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