G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 27/414 (2006.01)
Patent
CA 2338456
The present invention relates to an assembly comprising a field-effect transistor having vertebrate cells, particularly cells of mammalian origin, more particularly myocardial cells, fixed thereon, an apparatus for extracellular electrophysiological recordings comprising the assembly and its use for testing potential pharmaceutically effective compounds, such as compounds having potentially cardiac physiologically effectiveness, or compounds having potential side effects, or potentially toxic compounds.
La présente invention concerne un ensemble comprenant un transistor à effet de champ ayant des cellules vertébrées, notamment des cellules d'origine mammifère, plus particulièrement des cellules myocardiques, fixées sur celui-ci, un appareil permettant d'effectuer des enregistrements électrophysiologiques extracellulaires comprenant l'ensemble et son utilisation pour tester des composés à efficacité pharmaceutique potentielle, tels que des composés ayant une efficacité physiologique cardiaque potentielle, ou des composés ayant des effets secondaires potentiels ou des composés potentiellement toxiques.
Knoll Wolfgang
Offenhauser Andreas
Moffat & Co.
Symbiosis Gmbh
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