C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2314677
A genetic locus associated with asthma is identified. The genes within the locus, ASTH1I and ASTH1J, and the regulatory sequences of the locus are characterized. The genes are used to produce the encoded proteins; in screening for compositions that modulate the expression or function of ASTH1 proteins; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to asthma.
On a identifié un locus génétique associé à l'asthme. On a caractérisé les gènes à l'intérieur du locus, ASTH1I et ASTH1J, et les séquences régulatrices du locus. On utilise les gènes pour produire les protéines codées, pour cribler les compositions modulant l'expression ou la fonction des protéines ASTH1, et pour étudier les voies physiologiques associées. On utilise également l'ADN pour le diagnostic de prédisposition génétique à l'asthme.
Brooks-Wilson Angela R.
Buckler Alan
Cardon Lon
Carey Alisoun H.
Galvin Margaret
Axys Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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