C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103
C07K 14/58 (2006.01) A61K 35/34 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1241646
ABSTRACT Diuretic and natriuretic extracts, at least partially characterized as peptides, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid. After precipitation of impurities by pH adjustment, the extract may be further purified chromato- graphically. Extracts injected into test rats resulted in 30-40 fold increases in sodium and chloride excretions within 5 - 10 minutes of injection. Urine volume rose 10-15 fold and potassium excretion doubled. The response was complete in 20 minutes and no similar changes in renal function were observed following injection of a similarly obtained ventricular extract.
421998
Gastle And Associates
Queen's University At Kingston
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