C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/502 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 497/04 (2006.01)
Patent
CA 2637658
The present invention relates to chemical compounds having a general formula (I) wherein A1, A2, C1, C2, D, L1, L2, Z and R1-8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer- related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
La présente invention concerne des composés chimiques répondant à la formule générale (I) dans laquelle A1, A2, C1, C2, D, L1, L2, Z et R1-8 sont définis dans le présent document, et des intermédiaires synthétiques en mesure de moduler diverses enzymes du récepteur de la protéine kinase, influençant ainsi divers états pathologiques liés aux activités de telles kinases. Par exemple, les composés sont en mesure de moduler la kinase de l~aurore, influençant ainsi le processus du cycle cellulaire et la prolifération cellulaire en vue de traiter un cancer et des pathologies liées au cancer. L~invention concerne également des compositions pharmaceutiques comprenant les composés et des procédés visant à traiter des états pathologiques liés à l~activité de la kinase de l~aurore.
Cee Victor J.
Deak Holly L.
Du Bingfan
Geuns-Meyer Stephanie D.
Hodous Brian L.
Amgen Inc.
Gowling Lafleur Henderson Llp
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