C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/502 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2682504
The present invention relates to chemical compounds having a general formula (I), wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
La présente invention concerne des composés chimiques présentant la formule générale (formule), dans laquelle A1-8, D,, L1, L2, R1, R6-8 et n sont tels que définis dans la description, et des intermédiaires de synthèse qui sont capables de moduler divers enzymes récepteurs de protéines kinases et d'influencer ainsi divers états pathologiques et troubles liés aux activités de ces kinases. Par exemple, ces composés sont capables de moduler la kinase Aurora, et d'influencer ainsi le processus du cycle cellulaire et de la prolifération cellulaire, pour le traitement des cancers et de maladies connexes. L'invention concerne également des compositions pharmaceutiques contenant les composés, ainsi que des méthodes de traitement d'états pathologiques liés à l'activité de la kinase Aurora.
Cee Victor J.
Deak Holly L.
Du Bingfan
Geuns-Meyer Stephanie D.
Hodous Brian L.
Amgen Inc.
Gowling Lafleur Henderson Llp
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