Aurora kinase modulators and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/502 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2732101

The present invention relates to chemical compounds having a general formula I (1) wherein A1-6, L1, R1, R4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinase proteins. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.

La présente invention concerne des composés chimiques ayant une formule générale I [INSÉRER LA STRUCTURE ICI] I dans laquelle A1-6, L1, R1, R4-6 et n sont présentement définis, et des intermédiaires de synthèse, qui sont capables de moduler différentes enzymes récepteur protéine kinase, de manière à influencer différents états et conditions pathologiques associés aux activités de telles protéine kinases. Par exemple, les composés sont capables de moduler la kinase Aurora de manière à influencer le processus de cycle cellulaire et de prolifération cellulaire pour traiter le cancer et des maladies associées au cancer. Linvention concerne en outre des compositions pharmaceutiques, comprenant les composés et des procédés de traitement détats pathologiques associés à lactivité de kinase Aurora.

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