Aza-heterocyclic compounds used to treat neurological...

Details Aza-heterocyclic compounds used to treat neurological... Aza-heterocyclic compounds used to treat neurological...

C - Chemistry, Metallurgy

07

D

C07D 263/06 (2006.01) A61K 31/40 (2006.01) A61K 31/4164 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 207/48 (2006.01) C07D 211/60 (2006.01) C07D 263/04 (2006.01) C07D 277/02 (2006.01) C07D 277/06 (2006.01) C07D 403/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2333964

The present invention is directed to novel carboxylic acids and isosteres of heterocyclic ring compounds of formula (I) which have multiple heteroatoms within the heterocyclic ring, novel derivatives containing N-linked diketos, sulfonamides, ureas and carbamates attached thereto, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, as well as for treating alopecia and promoting hair growth. A, X, Y, Z, D and n are as defined in the application.

La présente invention concerne de nouveaux acides carboxyliques et isostères de composés de la formule (I) ayant un noyau hétérocyclique à plusieurs hétéroatomes, A, X, Y,Z, D et n étant, dans ladite formule, tels que définis dans le mémorandum descriptif. L'invention concerne également de nouveaux dérivés contenant des dicétones à liaison N, des sulfonamides, des urées et des carbamates attachés auxdits dérivés. L'invention concerne en outre la préparation desdits composés et leur utilisation pour traiter des troubles neurologiques (y compris des nerfs physiquement altérés) et de maladies neurodégénératives, ainsi que pour traiter l'alopécie et activer la pousse des cheveux.

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