Azaprostacyclins, process for their manufacture and their...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/52 (2006.01) C07C 57/03 (2006.01) C07C 57/13 (2006.01) C07C 57/26 (2006.01) C07C 57/52 (2006.01) C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1205468

ABSTRACT OF THE DISCLOSURE The present invention provides a compound of the general formula Image in which R1 represents a hydrogen atom or an alkyl group with 1 to 5 carbon atoms, W represents a -CH-OH group in which the OH group may have an .alpha.- or .beta.-configuration, R2 is a hydroxy group, R3 and R4 may be the same or different and each repre- sent a hydrogen atom, or an alkyl radical having 1 to 5 carbon atoms, D represents an alkylene radical having 1 or 2 carbon atoms, R5 represents a hydrogen atom or an alkyl radical having 1 or 2 carbon atoms, or, when D represents an alkylene radical with 2 carbon atoms, together with R6 represents a bond, R6 and R7 may be the same or different and each repre- sents a hydrogen atom or an alkyl radical having 1 or 2 carbon atoms, or R6(R7) represents a halogen atom when R7(R6) re- presents an alkyl radical having 1 or 2 carbon atoms, or R5 and R7 represent hydrogen or alkyl having 1 or 2 carbon atoms and D and R6 are members of a ring closed by (CH2)1-3 with D as Image and R6 as -CH2- and where R1 is a hydrogen atom or a salt thereof with a physiologically tolerable base. These compounds have a blood-pressure reducing and bronchodi- latory action. The invention also provides certain inter- mediates used in thier preparation.

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