Azetidinone derivatives and methods of use thereof

Details Azetidinone derivatives and methods of use thereof Azetidinone derivatives and methods of use thereof

A - Human Necessities

61

K

A61K 31/438 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2663503

The present invention relates to methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering a compound having the formula (I) or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof, wherein: R1 and R2 are defined in Tables 1-6 herein, and R3 is -phenyl, -4-chlorophenyl, -2-pyridyl, or -3-pyridyl.

La présente invention concerne des procédés pour traiter ou prévenir un trouble du métabolisme lipidique, la douleur, le diabète, un état vasculaire, une démyélination ou une stéatose hépatique non alcoolique, lesdits procédés comportant l'administration d'un composé ayant la formule (I) ou un sel pharmaceutique acceptable, un solvate, un ester, un promédicament ou un stéréoisomère de celui-ci, formule dans laquelle : R1 et R2 sont définis dans les Tableaux 1-6 par les présentest, et R3 est -phényle, -4-chlorophényle, -2-pyridyle, ou -3-pyridyle.

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