Azo-substituted pyridine and pyrimidine derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/50 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2734488

The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defmed herein. Compositions comprising such compounds are also pro- vided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.

La présente invention porte sur des composés de Formule (I) : (la formule chimique devrait être insérée ici telle qu'elle apparaît sur l'abrégé sous forme papier) (I) et sur des tautomères, isomères et esters desdits composés, et sur des sels, solvates et promédicaments pharmaceutiquement acceptables desdits composés, formule dans laquelle chacun parmi R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 et n est sélectionné indépendamment et tel que défini présentement. L'invention porte également sur des compositions comprenant de tels composés. Les composés de l'invention sont efficaces en tant qu'inhibiteurs du VHC, et sont utiles, seuls et conjointement avec d'autres agents thérapeutiques, dans le traitement ou la prévention de maladies ou de troubles tels que des infections virales et des troubles liés à des virus.

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