B cell tolerance induction

Details B cell tolerance induction B cell tolerance induction

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 5/0781 (2010.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2701739

The present invention relates to the induction of immune tolerance, by a novel method of induction of IL-10 production in B cells, whereby said B cells can be loaded with antigen before, during or after the induction of the IL-10 production. More specifically, the invention relates to the transduction of the B cell with a retroviral vector encoding an antigen, whereby the retroviral envelop induces IL-10 production in the B cell by activation the TLR2 receptor, in combination with its viral receptor.

La présente invention concerne l'induction d'une tolérance immunitaire, par un nouveau procédé d'induction de la production de IL-10 dans les lymphocytes B, lesdits lymphocytes B pouvant être chargés avec un antigène avant, pendant ou après l'induction de la production d'IL-10. Plus spécifiquement, l'invention concerne la transduction de lymphocytes B avec un vecteur rétroviral codant pour un antigène, l'enveloppe rétrovirale induisant la production d'IL-10 dans les lymphocytes B par l'activation du récepteur TLR2, en combinaison avec son récepteur viral.

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