C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2412377
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T- cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7- related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
L'invention concerne des acides nucléiques codant des facteurs apparentés à B7 modulant l'activation de cellules de réaction immune ou inflammatoire, telles que les lymphocytes T. Elle concerne également des vecteurs d'expression et des produits génétiques de fusion composés d'acides nucléiques codant des polypeptides apparentés à B7, y compris BSL1, BSL2 et BSL3. Elle concerne, de plus, des polypeptides isolés apparentés à B7, des protéines de fusion isolées comprenant des polypeptides apparentés à B7, et des anticorps réagissant de façon spécifique avec ces polypeptides apparentés à B7 ou avec certaines de leurs parties. Elle concerne également des essais mettant en application des acides nucléiques, des polypeptides ou des peptides apparentés à B7. Elle concerne également des compositions d'acides nucléiques, de polypeptides, de protéines de fusion ou d'anticorps apparentés à B7 et utiles pour exercer une immunomodulation chez un sujet humain ou animal.
Chang Han
Finger Joshua N.
Lu Pin
Mikesell Glen E.
Peach Robert
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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