Bacterial cell component-unresponsive model mouse

Details Bacterial cell component-unresponsive model mouse Bacterial cell component-unresponsive model mouse

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2509345

A knockout mouse which is unresponsive to peptidoglycan, a lipoprotein/lipopeptide and the like, and is useful for elucidating the contribution of individual members of the TLR family to a signaling stimulated with bacterial cell components in vivo, in particular, the role of TLR2 and MyD88 in vivo. A bacterial cell component-unresponsive knockout mouse is generated by a process comprising the steps of: a targeting vector is constructed by replacing a whole or a part of a gene fragment of an exon region containing a cytoplasmic region of TLR2 or MyD88 gene and the like with a plasmid having a poly A signal and a marker gene; the targeting vector is introduced into an embryonic stem cell; the targeting embryonic stem cell having a homologously recombined TLR2 or MyD88 gene is microinjected into the blastocyst of a mouse and the blastocyst is put back into the uterus of a recipient mouse.

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