Benz(b)azepine-2,5-diones useful in the treatment of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2161251

Antagonists at the NMDA receptor complex which are benz[b]azepines of formula (I) having a hydroxy, alkoxy or arnino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

L'invention concerne des antagonistes agissant au niveau du complexe de récepteurs de NMDA qui sont des benz(b)azépines de la formule (I), possèdant un substituant hydroxy, alcoxy ou amino à la position 3 et un substituant alcényle, alkynyle, aryle ou hétéroaryle à la position 4. De tels antagonistes sont utilisés dans le traitement d'attaques cérébrales et/ou d'autres troubles neurodégénératifs.

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