A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/17 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2600773
Mucositis is the result of a complex process of interactive biologic phenomena that take place in both the epitelium and the submucosa, often leading to severe pain and increased risk of dangerous systemic infections. Mucositis is often a side effect during chemotherapy and radiation therapy. The benzamidine derivatives herein described are particularly effective for treating and preventing mucositis since they are acting simultaneously at the several phases that characterize this disease.
La mucosite est le résultat d'un processus complexe de phénomènes biologiques interactifs se produisant à la fois dans l'épithélium et dans la sous-muqueuse, et entraîne souvent des douleurs importantes et un risque accru de contracter des infections systémiques dangereuses. La mucosite est souvent un effet secondaire des traitements de chimiothérapie et de radiothérapie. Les dérivés de benzamidine faisant l'objet de la présente invention sont particulièrement efficaces pour le traitement et la prévention des mucosites du fait qu'il agissent à la fois dans toutes les différentes phases caractérisant cette maladie.
Artusi Roberto
Caselli Gianfranco
D'amato Massimo Maria
Giordani Antonio
Letari Ornella
Macrae & Co.
Rottapharm S.p.a.
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