Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 1/00 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2607280

The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I), wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. The invention further relates to crystalline forms of a compound of formula (I).

La présente invention concerne des composés agonistes du récepteur 5-ht4T benzimidazole-carboxamide représentés par la formule (I), dans laquelle R1 et X sont tels que définis dans les spécifications ou un sel, un solvant ou un stéréoisomère de ceux-ci répondant aux normes pharmaceutiques. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces composés, des procédés d'utilisation de ces composés pour traiter des maladies associées à l'activité du récepteur5-HT4 et, des processus et des intermédiaires qui conviennent pour préparer ces composés. Cette invention concerne aussi des formes cristallines d'un composé représenté par la formule (I).

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