Benzocycloheptene derivatives as estrogens having selective...

Details Benzocycloheptene derivatives as estrogens having selective... Benzocycloheptene derivatives as estrogens having selective...

C - Chemistry, Metallurgy

07

C

C07C 39/14 (2006.01) A61K 31/05 (2006.01) A61K 31/055 (2006.01) A61P 5/30 (2006.01) A61P 15/00 (2006.01) C07C 39/23 (2006.01) C07C 39/42 (2006.01)

Patent

CA 2700759

The present invention describes non-steroidal compounds of the general Formula (I) in which A is Formula (II) in which X1 means one or more groups on the phenyl rinq and represents independently of one another a halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C3-C6)cycloalkyl-O, (C1-C14)acyl-O, (C1C4)alkenyl, (C1-C4)alkynyl, perfluoro(C1C4)alkyl radical, -CHO or CN, and X2 means one or more groups on the phenyl ring and represents independently of one another an H, halogen, OH, (C1C4)alkyl, (C1C4)alkyl-O, (C1-C4)Jalkenyl, (C1-C4)alkynyl, perfluoro- (C1C4)alkyl radical, -CHO or CN, as Estrogens.

La présente invention concerne des composés non-stéroïdiens de formule générale (I) dans laquelle A représente la formule (II) dans laquelle X1 signifie un ou des groupes sur le cycle phényle et représente(nt) indépendamment les uns des autres un halogène, OH, alkyle en C1 à C4, alkyle-O en C1 à C4, cycloalkyle-O en C3 à C6, acyle-O en C1 à C14, alcényle en C1 à C4, alcynyle en C1 à C4, radical perfluoroalkyle en C1 à C4, -CHO ou CN, et X2 signifie un ou des groupes sur le cycle phényle et représente(nt) indépendamment les uns des autres un H, halogène, OH, alkyle en C1 à C4, alkyle-O en C1 à C4, alcényle en C1 à C4, alcynyle en C1 à C4, radical perfluoroalkyle en C1 à C4, -CHO ou CN, comme strogènes.

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