Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) C07D 243/24 (2006.01) C07D 243/26 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2196062

Benzodiazepine derivatives of formula (I) wherein R1 is aryl which may have one or more suitable substituent(s), R2 is C3-C8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, furyl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, benzopyranyl, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.

L'invention se rapporte à des dérivés de benzodiazépine de la formule (I) dans laquelle R?1¿ représente un aryle pouvant avoir un ou plusieurs substituants appropriés, R?2¿ représente cycloalkyle en C¿3?-C¿8? pouvant avoir un ou plusieurs substituants appropriés, A représente alkylène inférieur, R?3¿ représente un groupe hétérocyclique sélectionné dans le groupe constitué par tétrahydrofuryle, dioxolanyle, furyle, thiényle, isoxazolyle, pyridyle, benzimidazolyle, benzothiazolyle, benzoxazolyle, benzopyranyle, quinolyle, isoquinolyle, tétrahydroisoquinolyle, benzothiényle et benzofuryle, chacun d'eux pouvant avoir un ou plusieurs substituants appropriés, ou à un sel pharmaceutiquement acceptable de ces dérivés, lesquels sont utilisés comme médicaments.

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