A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/5513 (2006.01) C07D 243/20 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2269135
Compounds having a benzodiazepine hydrazide core are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
L'invention porte sur des composés possédant un noyau de benzodiazépine hydrazide. Ces composés sont utilisés dans l'inhibition de l'intégrase du VIH, la prévention ou le traitement des infections à VIH et dans le traitement du SIDA, que ce soit des composés, des sels pharmaceutiquement acceptables, des ingrédients de compositions pharmaceutiques, en combinaison ou non avec d'autres agents antiviraux, des immunomodulateurs, des antibiotiques ou des vaccins. Des procédés de traitement du SIDA et des procédés de prévention ou de traitement des infections à VIH sont également décrits.
Bell Ian M.
Guare James P. Jr.
Hazuda Daria Jean
Munson Peter M.
Thompson Wayne J.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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