Benzodioxane imidazoline compounds as antihypertensives

Details Benzodioxane imidazoline compounds as antihypertensives Benzodioxane imidazoline compounds as antihypertensives

C - Chemistry, Metallurgy

07

D

167/237, 260/305

C07D 405/06 (2006.01) A61K 31/415 (2006.01) C07D 319/20 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1185606

ABSTRACT OF THE DISCLOSURE Compounds of the formula Image (I) and the pharmaceutically acceptable acid addition salts thereof, wherein: n is an integer equal to 0, 1, 2 or 3; R1 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenyl lower alkyl; each R is independently hydrogen, lower alkyl, optionally substituted phenyl, or optionally substituted phenyl lower alkyl; are .alpha.2 blockers, and, therefore, are useful in treating essential hypertension and depression, and in inhibiting platelet aggregation.

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