Benzofuran derivatives

Details Benzofuran derivatives Benzofuran derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 405/14 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2068756

- 85 - CV317/EP ABSTRACT BENZOFURAN DERIVATIVES The invention provides compounds of the general formula (I): Image or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein R1 represents a hydrogen atom or a halogen atom or a group selected from C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, C1-6alkoxy ,-CHO, -CO2H or -COR2; Ar represents the group Image ; R2 represents a gr.oup selected from C1-6alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR15R16; R3 represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R4 and R5 which may be the same or different each independently represent a hydrogen atom or a halogen atom or a C1-6alkyl group; Het represents the group Image A represents a variety of 4-membered optionally substituted linkages; - 86 - CV317/EP R6 represents a hydrogen atom or a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkylthio, C1-6alkoxy, C3-7cycloalkyl, or C3-7cycloalkylC1-4alkyl; and R15 and R16, which may be the same or different, each independently represent a hydrogen atom or a C1-4alkyl group or -NR15R16 forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

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