Benzofuranoxyethylamines as antidepressants and anxiolytics

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/404 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2516263

The invention relates to novel benzofuran oxyethylamines of formula (I), wherein R1, R2, R3, R4, m and n have the meanings as cited in Patent Claim No. 1, which have a strong affinity to the 5HT1A receptors and/or 5HT1D receptors. The compounds inhibit the reuptake of serotonin, exhibit serotonin-agonistic and serotonin-antagonistic properties and are suited for use antidepressant drugs, anxiolytic drugs, antipsychotic drugs, neuroleptic drugs and/or antihypertonic drugs.

L'invention concerne des benzofuranoxyéthylamines représentées par la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, m et n ont la signification donnée dans la revendication (1), lesdits composés présentant une grande affinité par rapport aux récepteurs 5 HT¿1A? et/ou aux récepteurs 5HT¿1D?. Lesdits composés inhibent le recaptage de la sérotonine, présentent des propriétés d'agonistes et d'antagonistes de la sérotonine, et peuvent servir d'antidépresseurs, d'anxiolytiques, d'antipsychotiques, de neuroleptiques et/ou d'antihypertoniques.

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