Beta-amino-alpha-hydroxycarboxylic acids and their use

Details Beta-amino-alpha-hydroxycarboxylic acids and their use Beta-amino-alpha-hydroxycarboxylic acids and their use

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/05 (2006.01) C07D 207/16 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2060844

ABSTRACT OF THE DISCLOSURE The compounds of the invention are .beta.-amino-.alpha.- hydroxycarboxylic acid derivatives having the formula (I): Image (I) wherein: R1 represents a group of formula R(Z)XA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula -NRaRb wherein Ra and Rb are hydrogen atoms, alkyl groups, unsubstituted or substituted cycloalkyl, heterocyclic, aralkenyl or aryl groups, Z represents oxygen or sulfur; A represents a group of formula -CO-, -COCO-, -SO-, -SO2- or -CS-; and x is the cipher 0 or the integer 1; R2 represents a hydrogen atom, or a substituted or unsubstituted alkyl group; R3 is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; R4 is a hydrogen atom, a substituted or unsubstituted alkyl, aryl or heterocyclic group; and R5 represents a group of formula -B-(CO)-Y-R?, wherein B represents a heterocyclic group unsubstituted or substituted with at least one alkyl group; Y represents an oxygen atom, a nitrogen atom or a sulfur atom; y is the integer 1 when Y represents an oxygen atom or a sulfur atom, and 2 when Y represents a nitrogen atom; and Rc represents is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group; and, where there are two groups or atoms represented by Rc, they are the same or different; and and pharmaceutically acceptable salts and esters thereof.

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