Beta carboline derivatives as antidiabetic compounds

Details Beta carboline derivatives as antidiabetic compounds Beta carboline derivatives as antidiabetic compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2693214

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treat-ment of depression and anxiety.

L'invention concerne des dérivés de bêta-carboline, de la formule structurelle I, qui sont des antagonistes sélectifs du récepteur 3 du sous-type somatostatine (SSTR3) et qui s'utilisent pour le traitement du diabète Mellitus de type 2 et des états qui sont souvent associés à cette maladie, y compris l'hyperglycémie, la résistance à l'insuline, l'obésité, les troubles lipidiques et l'hypertension. Les composés s'utilisent également pour le traitement de la dépression et de l'anxiété.

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