A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7076 (2006.01) A61K 31/7052 (2006.01) A61K 31/7064 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 38/21 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2498731
It has been discovered that .szlig.-L-2'-deoxynucleosides are active against drug~resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a .szlig.-L-2'~deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. In addition, a method for preventing lamivudine resistant HBV (M552V) mutation from occurring in a naïve host is provided that includes administering a .szlig.-L-2'-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. A method for preventing and/or suppressing the emergence of the HBV double mutant (L528M/M552V) in a host is also provided that includes administering a (3-L-2'-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.
On a découvert que les .szlig.-L-2'-désoxynucléosides étaient actifs contre les virus mutants de l'hépatite B résistant aux médicaments. Dans ce cadre, l'invention porte sur un procédé de traitement du VHB (M552V) résistant à la lamivudine dans un hôte consistant à lui administrer un .szlig.-L-2'-désoxynucléoside ou ses sels, esters ou promédicaments pharmacocompatibles. L'invention porte également sur un procédé empêchant les mutations du VHB (M552V) résistant à la lamivudine de se produire dans un hôte naïf, consistant à lui administrer un .szlig.-L-2'-désoxynucléoside ou ses sels, esters ou promédicaments pharmacocompatibles, et sur un procédé prévenant et/ou supprimant l'apparition dans un hôte d'un double mutant du VHB (L528M/M552V), consistant à lui administrer un .szlig.-L-2'-désoxynucléoside ou ses sels, esters ou promédicaments pharmacocompatibles
Patty April L.
Seifer Maria
Sommadossi Jean-Pierre
Standring David
Idenix (cayman) Limited
Mbm Intellectual Property Law Llp
Novartis Ag
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