Beta-strand mimetics and methods relating thereto

Details Beta-strand mimetics and methods relating thereto Beta-strand mimetics and methods relating thereto

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2527375

Conformationally constrained compounds which mimic the secondary structure of .szlig.-strand regions of biologically active peptides and proteins are disclosed. Such .szlig.-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the .szlig.-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.

Des composés à contrainte conformationnelle qui imitent la structure secondaire des zones de brin .beta. de protéines et de peptides actifs au plan biologique sont décrits. Lesdites structures mimétiques de brin .beta. ont une utilité dans une grande gamme de domaines, notamment dans l'utilisation en tant qu'agents diagnostiques et thérapeutiques. Des banques contenant les structures mimétiques de brin .beta. de l'invention sont également décrites ainsi que de méthodes de criblage desdites structures pour l'identification d'éléments actifs au plan biologique.

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