Betulinol derivatives as anti-cancer agents

Details Betulinol derivatives as anti-cancer agents Betulinol derivatives as anti-cancer agents

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/56 (2006.01) A61K 31/575 (2006.01) C07J 63/00 (2006.01)

Patent

CA 2607177

The present invention relates to a method of treating cancer selected from the group of cancers consisting of prostate cancer, renal cancer, breast cancer, ovarian cancer, CNS cancer, melanoma, lung cancer, and bladder cancer. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a betulinol derivative compound of Formula (I). Also disclosed are conjugated and immunoconjugated derivatives of the compound of Formula (I) as well as methods of making and using them.

L'invention concerne une méthode de traitement d'un cancer choisi dans le groupe de cancers constitué par le cancer de la prostate, le cancer du rein, le cancer du sein, le cancer de l'ovaire, le cancer du SNC, le mélanome, le cancer du poumon et le cancer de la vessie. Cette méthode consiste à administrer à un patient nécessitant un tel traitement une quantité thérapeutiquement efficace d'un composé dérivé de bétulinol de formule I. L'invention concerne également des dérivés conjugués et immunoconjugués du composé de formule I, ainsi que des méthodes de fabrication et d'utilisation associées.

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