Biarylalkanoic acids as cell adhesion inhibitors

Details Biarylalkanoic acids as cell adhesion inhibitors Biarylalkanoic acids as cell adhesion inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/09 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/41 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) C07D 207/08 (2006.01) C07D 207/48 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) A61K 38/05 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01)

Patent

CA 2291762

Compounds of formula (I) are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell- adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

Des composés de formule (I) sont des antagonistes de VLA-4 et/ou de .alpha.¿4?.beta.¿7?, et sont, en tant que tels, utiles pour inhiber ou prévenir l'adhésion cellulaire et pour lutter contre des pathologies induites par l'adhésion cellulaire. Ces composés peuvent être formulés sous forme de compositions pharmaceutiques et sont appropriés pour être utilisés dans le traitement de l'asthme, des allergies, de l'inflammation, de la sclérose en plaques et d'autres maladies inflammatoires et auto-immunes.

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