C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/317, 204/43.
C07D 209/42 (2006.01) C07D 209/08 (2006.01) C07D 209/34 (2006.01) C07D 209/52 (2006.01) C07D 215/227 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1206478
Abstract of the Disclosure The invention provides compounds of the formula III", Image III" wherein n represents a whole number from 0 to 2, W' represents hydrogen, alkyl having 1 to 18 C atoms or aralkyl having 7 to 10 C atoms, and R3, R4 and R5 represent hydrogen and the H atoms on the C atoms 3a and (6+n) a have the cis or trans configuration relative to one another, wherein the case of the cis configuration, the group -CO2W' on C atom 2 is orientated exo to the bicyclic ring system, or R3 and R4 or R4 and R5 together each denote a chemical bond and R3 or R5 denotes hydrogen, and a process for the preparation thereof. Compounds of the formula III" are useful starting materials in the synthesis of bicyclic aminoacids having long lasting and powerful hypotensive activity.
461836
Becker Reinhard
Gaul Holger
Geiger Rolf
Henning Rainer
Teetz Volker
Aventis Pharma Deutschland Gmbh
Becker Reinhard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Gaul Holger
Geiger Rolf
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