Bicyclic heterocycles as neurokinin a antagonists

Details Bicyclic heterocycles as neurokinin a antagonists Bicyclic heterocycles as neurokinin a antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/395 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2175701

Compounds of formula (I) wherein Q1, m and M have any of the meanings given in the specification, their <u>N</u>-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.

On décrit des composés de formule (I) où Q?1¿, m et M représentent l'un ou l'autre des éléments figurant dans la description. Avec leurs oxydes <u>N</u> et leurs sels pharmacologiquement acceptables, ils constituent des antagonistes non peptidiques de la neurokinine A et se révèlent utiles pour traiter l'asthme, etc. On décrit aussi des compositions et procédés pharmaceutiques permettant de préparer des composés de formule (I) et leurs intermédiaires.

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