Bicyclic piperazines as metabotropic glutamate receptor...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2616308

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A Hy, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR5-mediated disorders.

L'invention concerne des composés de formule I ou des sels pharmaceutiquement acceptables ou des solvates de ceux-ci: où Ar1, A Hy, R1, m et n sont tels que définis dans la description. L'invention porte également sur des compositions pharmaceutiques et des utilisations de celles-ci, sur des procédés de fabrication desdits composés ainsi que sur des procédés de traitement médical de troubles médiés par mGluR5.

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