Bicyclic prostaglandins and process for their preparation

Details Bicyclic prostaglandins and process for their preparation Bicyclic prostaglandins and process for their preparation

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/935 (2006.01)

Patent

CA 1183841

ABSTRACT OF THE DISCLOSURE The invention provides a compound of formula I (I) Image wherein R is a free or esterified carboxy group; Y is -CH2-CH2- or -CH=CH-trans; R2 is hydrogen; R5 is hydroxy; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; n1 is zero or an integer of 1 to 6; n2 is zero, 1 or 2; X is -O- or -(CH2)m-, wherein m is zero or 1; R6 is hydrogen, C1-C4 alkyl or an unsubstituted C3-C9 cycloaliphatic radical, provided that (a) when X is -O- and n2 is zero R6 is C1-C4 alkyl or an unsubstituted C3-C9 cycloaliphatic radical; (b) when X is -O- and n2 is 1 or 2 R6 is C1-C4 alkyl and (c) when X is -(CH2)m- R6 is hydrogen or C1-C4 alkyl and n1 is zero, 1 or 2, n2 is zero, and the pharmaceu- tically or veterinarily acceptable salts thereof.

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