Bicyclic pyrimidine matrix metalloproteinase inhibitors

Details Bicyclic pyrimidine matrix metalloproteinase inhibitors Bicyclic pyrimidine matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61P 29/00 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2436371

Selective MMP-13 inhibitors are bicyclic pyrmidines of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; R2, R3, and R4 include hydrogen, halo, alkyl, C.ident.C(CH2)m aryl; and X is O, S, SO, SO2, CH2, C=O, CHOH, NH, OR NR5. A compound of the formula, or a pharmaceutically acceptable salt thereof, is useful for treating cancer or arthritis.

L'invention concerne des inhibiteurs MMP-13 sélectifs comme des pyrimidines bicycliques de formule ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle R?1¿ représente l'hydrogène ou l'alkyle; R?2¿, R?3¿, et R?4¿ comprennent l'hydrogène, halo, alkyle, C.ident.C(CH¿2?)¿m? aryle et X représente O, S, SO, SO¿2?, CH¿2?, C=O, CHOH, NH, ou NR?5¿. un composant de la formule ou un sel pharmaceutiquement acceptable de celui-ci sert à traiter le cancer ou l'arthrite.

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