C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/01 (2006.01) C07D 498/22 (2006.01) C07D 519/00 (2006.01) A61K 31/71 (1990.01)
Patent
CA 2069469
AHP-9807 ABSTRACT A bicyclic derivative of rapamycin of general formula (1) Image (1) wherein A is -(CH2)n, or -(CH2)n-(CH=CH)-(CH2)m-, or -(CH2)n-(CH?CH)-(CH2)m-, or Image ; n = 2 to 10, m = 2 to l0 and n = m or n ? m or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
Kao Wenling
Musser John H.
Vogel Robert L.
American Home Products Corporation
Kao Wenling
Musser John H.
Ridout & Maybee Llp
Vogel Robert L.
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